Belgium and Manchester City captain Vincent Kompany will miss Euro 2016 with a groin injury, according to a statement on his Facebook page.
The defender, 30, was was substituted after 10 minutes of City’s Champions League semi-final second-leg defeat by Real Madrid on Wednesday.
Kompany has suffered five separate injuries this season, playing just 22 matches out of a possible 57.
He said it was “very sad news” but promised he would not “give up”.
The statement added: “I trust my friends and team-mates to do well and do us proud at the next European Championships in France.
“I am now officially their most fervent supporter and I will be there to support them.”
Belgium are grouped with Italy, Sweden and the Republic of Ireland at this summer’s tournament.
Chelsea’s Eden Hazard is Belgium’s vice-captain and has led the side in previous games when Kompany has been unavailable.
More to follow.